Can you take Clobazam with Thiopental?
1 drug interaction and 15 additional warnings found for the following 2 drugs:
- clobazam
- thiopental
Drug interactions
Moderate drug interactions
Moderate:
thiopental cloBAZam
Applies to: thiopental and clobazam
Using thiopental together with cloBAZam may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
thiopental Alcohol (Ethanol)
Applies to: thiopental
Ask your doctor before using thiopental together with ethanol (alcohol), this can add to dizziness, drowsiness and other side effects of thiopental. Be careful if you drive or do activities that require you to be awake and alert. Talk with your doctor before using any medications together, or drinking alcohol with thiopental. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate food/lifestyle interactions
Moderate:
cloBAZam Food/Lifestyle
Applies to: clobazam
Alcohol can increase the nervous system side effects of cloBAZam such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloBAZam. Do not use more than the recommended dose of cloBAZam, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
13 potential interactions Applies to: 12 conditions, including Depression, Asthma, Anemia, Psychosis, and Myasthenia Gravis.
Acute Alcohol Intoxication
Major:
clobazam
cloBAZam has a major potential interaction with Acute Alcohol Intoxication.
The use of benzodiazepines with alcohol is not recommended. Patients with acute alcohol intoxication exhibit depressed vital signs. The central nervous system depressant effects of benzodiazepines may be additive with those of alcohol, and severe respiratory depression and death may occur. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.
Adrenal Insufficiency
Major:
thiopental
Thiopental has a major potential interaction with Adrenal Insufficiency.
Thiopental should not be used in patients with Addison disease or any adrenal gland disorder.
Anemia
Major:
thiopental
Thiopental has a major potential interaction with Anemia.
Thiopental should not be used in patients with severe anemia.
Asthma
Major:
thiopental
Thiopental has a major potential interaction with Asthma.
Thiopental should not be used in patients with asthma as it can lead to intraoperative bronchospasm which can be catastrophic.
Depression
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Depression.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Drug Dependence
Major:
clobazam
cloBAZam has a major potential interaction with Drug Dependence.
Benzodiazepines have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use and/or excessive dosages. However, abrupt cessation following continual use of as few as 6 weeks at therapeutic levels has occasionally precipitated withdrawal symptoms. Addiction- prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance when treated with benzodiazepines. It may be prudent to refrain from dispensing large quantities of medication to these patients. After prolonged use or if dependency is suspected, withdrawal of benzodiazepine therapy should be undertaken gradually using a dosage- tapering schedule. If withdrawal symptoms occur, temporary reinstitution of benzodiazepines may be necessary.
Liver Disease
Major:
thiopental
Thiopental has a major potential interaction with Liver Disease.
Thiopental should not be used in patients with liver dysfunction. The distribution half-life and the duration of the drug action will be prolonged.
Myasthenia Gravis
Major:
thiopental
Thiopental has a major potential interaction with Myasthenia Gravis.
Thiopental should not be used in patients with myasthenia gravis as it can prompt myasthenic crises.
Porphyria
Major:
thiopental
Thiopental has a major potential interaction with Porphyria.
The use of thiopental is contraindicated in patients with porphyria.
Psychosis
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Psychosis.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Renal Dysfunction
Major:
thiopental
Thiopental has a major potential interaction with Renal Dysfunction.
Thiopental should not be used in patients with renal impairment. If so, the dose needs to be considerably reduced.
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Renal Dysfunction.
Benzodiazepines are excreted by the kidneys and should be used with caution in patients with impaired renal function and end-stage kidney disease.
Thyroid Disease
Major:
thiopental
Thiopental has a major potential interaction with Thyroid Disease.
Thiopental should not be used in patients with thyroid disorder as it influences thyroid metabolism.
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More resources
clobazam
A total of 537 drugs are known to interact with clobazam.
- Clobazam is in the following drug classes: benzodiazepine anticonvulsants, benzodiazepines.
- Clobazam is used to treat the following conditions:
thiopental
A total of 278 drugs are known to interact with thiopental.
- Thiopental is in the drug class general anesthetics.
- Thiopental is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.