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Drug Interactions between Cleviprex and Renocal-76

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

diatrizoate clevidipine

Applies to: Renocal-76 (diatrizoate) and Cleviprex (clevidipine)

MONITOR: Coadministration of calcium channel blockers may increase the cardiovascular effects of ionic X-ray contrast media. The mechanism is unknown. A study involving 125 patients undergoing bolus contrast left ventriculography found that the hemodynamic effect of a bolus dose of an ionic agent (0.5 mL/kg of diatrizoate meglumine and diatrizoate sodium or diatrizoate meglumine and diatrizoate sodium with edetate calcium) was increased in 65 patients receiving nifedipine or diltiazem compared to 60 patients not receiving these drugs. In the patients receiving nifedipine or diltiazem in addition to ionic contrast, the hypotensive response occurred earlier (4.2 seconds versus 12.9 seconds), was more profound (maximal decrease in systolic arterial pressure was 48.5 mmHg versus 36.9 mmHg), and was more prolonged (62.3 seconds versus 36.4 seconds) than in the patients receiving ionic contrast alone. There was no difference in the hemodynamic effect of a nonionic contrast agent, iopamidol, used alone compared to nifedipine or diltiazem used in addition to iopamidol.

MANAGEMENT: Patients taking calcium channel blockers should be closely monitored for increased cardiovascular effects of ionic X-ray contrast media, such as hypotension. Use of a nonionic contrast agent, such as iopamidol, may be considered instead of ionic contrast where clinically appropriate.

References

  1. Morris DL, Wisneski JA, Gertz EW, et al. "Potentiation by nifedipine and diltiazem of the hypotensive response after contrast angiography." J Am Coll Cardiol 6 (1985): 785-91
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

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Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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