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Drug Interactions between Citrucel and Linzess

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

methylcellulose linaclotide

Applies to: Citrucel (methylcellulose) and Linzess (linaclotide)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Moderate

methylcellulose food

Applies to: Citrucel (methylcellulose)

Methylcellulose may interact with other medications if given at the same time. This can cause your other medications to become less effective. In general, all oral medications should be administered at least 2 hours before or 2 hours after dosing of methylcellulose. Take methylcellulose with a full glass (at least 8 ounces) of cool water or another liquid. Taking methylcellulose without enough liquid may cause it to swell in the throat and cause choking.

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Moderate

linaclotide food

Applies to: Linzess (linaclotide)

Taking linaclotide with food may increase gastrointestinal side effects such as diarrhea, abdominal pain, and gas. The absorption of any other oral medication you may take can be affected if you develop frequent or severe diarrhea. To reduce the risk of gastrointestinal intolerance, linaclotide should be taken on an empty stomach at least 30 minutes prior to the first meal of the day. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.