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Drug Interactions between cisplatin and Hycamtin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

CISplatin topotecan

Applies to: cisplatin and Hycamtin (topotecan)

MONITOR CLOSELY: Topotecan combined with a platinum agent may produce synergistic cytotoxicity against some germ cell cancers. However, myelosuppression may also be more severe. In a reported study where patients were given cisplatin 50 mg/m2 and topotecan 1.25 mg/m2/day for 5 days, one of three patients had severe neutropenia for 12 days and a second patient died with neutropenic sepsis. The interaction appears to be sequence-dependent. Specifically, coadministration of a platinum agent on day 1 of topotecan dosing required lower dosages of each agent compared to coadministration on day 5 of the topotecan dosing schedule.

MANAGEMENT: There are currently insufficient data to recommend a safe and effective regimen for topotecan in combination with a platinum agent. Clinicians should recognize the potential risk for severe neutropenia if these agents are used together, and bone marrow function must be closely monitored. Lower dosages of each agent may be required.

References

  1. Chou TC, Motzer RJ, Tong Y, Bosl GJ (1994) "Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design." J Natl Cancer Inst, 86, p. 1517-24
  2. Rowinsky E, Grochow L, Kaufmann S, Bowling K, Sartorius S, Chen T, Lubejko B, Ettinger D, Peereboom D, Donehower R (1994) "Sequence-dependent effects of topotecan (T) and cisplatin (C) in a Phase I and pharmacokinetic (PK) study (Meeting abstract)." Proc Annu Meet Am Soc Clin Oncol, 13, a3611994
  3. (2001) "Product Information. Hycamtin (topotecan)." SmithKline Beecham

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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