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Drug Interactions between cholera vaccine, live and influenza virus vaccine, live

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

influenza virus vaccine, live cholera vaccine, live

Applies to: influenza virus vaccine, live and cholera vaccine, live

The safety and immunogenicity of live influenza virus vaccines when administered concurrently with other vaccines have not been determined. Clinical studies for FluMist (live influenza virus vaccine intranasal spray) have excluded subjects who received any inactivated or subunit vaccine within two weeks of enrollment. Data concerning use with live vaccines are limited to the measles, mumps and rubella vaccine and the varicella vaccine. In a study consisting of 1,245 children 12 to 15 months of age, adverse events observed during concurrent administration of FluMist with these vaccines were similar to the adverse effects reported in other clinical trials for FluMist. No evidence of interference with immune responses to any of the study vaccines was observed. Concurrent administration in children greater than 15 months of age has not been studied.

References (2)
  1. (2022) "Product Information. FluMist (influenza virus vaccine, live)." Medimmune Inc
  2. (2022) "Product Information. Influenza Virus Vaccine, H1N1, Live (influenza virus vaccine, H1N1, live)." Medimmune Inc

Drug and food interactions

Moderate

cholera vaccine, live food

Applies to: cholera vaccine, live

ADJUST DOSING INTERVAL: Coadministration of oral cholera vaccine with food or an oral beverage may impair its efficacy. The formulations of both the inactivated and live, attenuated oral cholera vaccines (Dukoral and Vaxchora, respectively) are acid-labile, and must be administered with a buffer. According to the manufacturer, eating and drinking may interfere with the protective effect of the buffer. However, clinical data are not available.

MANAGEMENT: It is recommended that patients avoid eating or drinking for 60 minutes before and after administration of either Dukoral or Vaxchora oral cholera vaccines.

References (4)
  1. (2023) "Product Information. Vaxchora (cholera vaccine, live)." Patientric Ltd
  2. (2022) "Product Information. Dukoral (cholera vaccine, inactivated)." Valneva Sweden AB
  3. (2023) "Product Information. Dukoral (cholera vaccine)." Valneva UK Ltd
  4. (2024) "Product Information. Vaxchora (cholera vaccine, live)." Emergent Travel Health, Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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