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Drug Interactions between chlorzoxazone and Daxxify

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

chlorzoxazone daxibotulinumtoxinA

Applies to: chlorzoxazone and Daxxify (daxibotulinumtoxinA)

MONITOR: Excessive muscle weakness associated with the use of botulism toxin may be exaggerated by concomitant use of a skeletal muscle relaxant. Botulinum toxin inhibits the release of acetylcholine from peripheral cholinergic nerve endings and is a neuromuscular blocking agent, thus additive effects may occur with muscle relaxants.

MANAGEMENT: Patients should be advised that muscle weakness may be increased when botulinum toxin is used in combination with skeletal muscle relaxants.

References (8)
  1. "Product Information. Myobloc (rimabotulinumtoxinB)." Elan Pharmaceuticals
  2. "Product Information. Dysport (abobotulinumtoxinA)." Tercica Inc
  3. "Product Information. Botox (onabotulinumtoxinA)." Allergan Inc
  4. (2022) "Product Information. Xeomin (incobotulinumtoxinA)." Merz Pharmaceuticals
  5. (2022) "Product Information. Jeuveau (prabotulinumtoxinA)." Evolus, Inc.
  6. (2022) "Product Information. Daxxify (daxibotulinumtoxinA)." Revance Therapeutics, Inc., 1
  7. (2022) "Product Information. Letybo (letibotulinumtoxinA)." CROMA Australia Pty Ltd, 1
  8. (2024) "Product Information. Letybo (letibotulinumtoxinA)." Hugel Aesthetics

Drug and food interactions

Moderate

chlorzoxazone food

Applies to: chlorzoxazone

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents such as chlorzoxazone. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills. In addition, in one small study, watercress was reported to increase chlorzoxazone peak concentrations, AUC, and half-life. The proposed mechanism is inhibition of CYP450 2E1 metabolism. The clinical significance is unknown.

MANAGEMENT: Patients receiving chlorzoxazone should be advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how chlorzoxazone affects them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities. Watercress should be avoided if an interaction is suspected; e.g., excess sedation, nausea, or headache occurs.

References (1)
  1. Leclercq I, Desager JP, Horsmans Y (1998) "Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress." Clin Pharmacol Ther, 64, p. 144-9

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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