Drug Interactions between Chenodal and Cholestyramine Light
This report displays the potential drug interactions for the following 2 drugs:
- Chenodal (chenodeoxycholic acid)
- Cholestyramine Light (cholestyramine)
Interactions between your drugs
cholestyramine chenodeoxycholic acid
Applies to: Cholestyramine Light (cholestyramine) and Chenodal (chenodeoxycholic acid)
ADJUST DOSING INTERVAL: Bile acid sequestering agents may bind to and decrease the gastrointestinal absorption of chenodeoxycholic acid, which is a naturally occurring human bile acid.
MANAGEMENT: As with other drugs whose absorption may be reduced by bile acid sequestering agents, chenodeoxycholic acid should be administered at least 4 hours before the bile acid sequestering agent. However, adjusting the dosing interval may not completely prevent the interaction.
References
- (2002) "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc
- (2001) "Product Information. Welchol (colesevelam)." Daiichi Sankyo, Inc.
- (2009) "Product Information. Chenodal (chenodeoxycholic acid)." Manchester Pharmaceutical
Drug and food interactions
cholestyramine food
Applies to: Cholestyramine Light (cholestyramine)
ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).
MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.
References
- (2001) "Product Information. Rocaltrol (calcitriol)." Roche Laboratories
- (2001) "Product Information. Welchol (colesevelam)." Daiichi Sankyo, Inc.
- (2005) "Product Information. Fosamax Plus D (alendronate-cholecalciferol)." Merck & Co., Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- Peirce D, Hossack S, Poole L, et al. (2011) "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant, 26, p. 1615-21
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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