Can you take Cervarix with Fruquintinib?
1 drug interaction and 12 additional warnings found for the following 2 drugs:
- Cervarix (human papillomavirus vaccine)
- fruquintinib
Drug interactions
Moderate drug interactions
Moderate:
human papillomavirus vaccine fruquintinib
Applies to: Cervarix (human papillomavirus vaccine) and fruquintinib
If you are currently being treated or have recently been treated with fruquintinib, you should let your doctor know before receiving human papillomavirus vaccine. Depending on the dose and length of time you have been on fruquintinib, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of fruquintinib therapy. If you have recently been vaccinated with human papillomavirus vaccine, your doctor may choose to postpone treatment with fruquintinib for a couple of weeks or more. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
12 potential interactions Applies to: 11 conditions, including High Blood Pressure, Hypotension, Fever, Syncope, and Liver Disease.
Bleeding Associated with Coagulation Defect
Moderate:
fruquintinib
Fruquintinib has a moderate potential interaction with Bleeding Associated with Coagulation Defect.
Fruquintinib increases the risk of hemorrhagic events which may lead to fatal outcomes. Closely monitor patients who are at risk for bleeding.
Bleeding Disorder
Moderate:
fruquintinib
Fruquintinib has a moderate potential interaction with Bleeding Disorder.
Fruquintinib increases the risk of hemorrhagic events which may lead to fatal outcomes. Closely monitor patients who are at risk for bleeding.
Dehydration
Moderate:
Cervarix
The human papillomavirus vaccine in Cervarix has a moderate potential interaction with Dehydration.
The administration of human papillomavirus vaccine has been associated with syncope, sometimes resulting in falling with injury. The syncope sometimes is associated with tonic-clonic movements and other seizure-like activity. Caution is recommended when administering the vaccine to individuals susceptible to syncope. Observation for 15 minutes is recommended after its administration.
Fever
Major:
Cervarix
The human papillomavirus vaccine in Cervarix has a major potential interaction with Fever.
Ideally, vaccination should occur when an individual is healthy, thus minimizing the risk of an adverse host reaction and/or vaccine failure. However, a current or recent infection does not necessarily preclude the use of vaccines, depending on the severity of the patient's symptoms and their etiology. Superficial infections and minor acute illnesses such as a mild upper respiratory infection with or without low-grade fever do not contraindicate immunization, particularly if prompt administration of a vaccine is deemed necessary or beneficial. In fact, when vaccines are administered during the course of a minor illness, the risk of adverse events is not increased, and serum antibody response is not often diminished. On the other hand, if fever or symptoms suggest a moderate or severe illness, it is usually appropriate to withhold vaccination until the patient has recovered. In addition to the potential risks already mentioned, evolving signs and symptoms of the illness can sometimes confound the diagnosis of a vaccine reaction if it develops. In the presence of any infection, the decision to administer or withhold/defer immunization should take into consideration the benefits versus the risks to an individual patient.
High Blood Pressure
Moderate:
fruquintinib
Fruquintinib has a moderate potential interaction with High Blood Pressure.
Hypertension was reported in patients taking fruquintinib. Fruquintinib should not be initiated in patients unless blood pressure is adequately controlled.
History, Thrombotic/Thromboembolic Disorder
Moderate:
fruquintinib
Fruquintinib has a moderate potential interaction with History, Thrombotic/Thromboembolic Disorder.
Fruquintinib may increase the risks for arterial thromboembolic events. Initiation of fruquintinib in patients with a recent history of thromboembolic events should be carefully considered.
Hypotension
Moderate:
Cervarix
The human papillomavirus vaccine in Cervarix has a moderate potential interaction with Hypotension.
The administration of human papillomavirus vaccine has been associated with syncope, sometimes resulting in falling with injury. The syncope sometimes is associated with tonic-clonic movements and other seizure-like activity. Caution is recommended when administering the vaccine to individuals susceptible to syncope. Observation for 15 minutes is recommended after its administration.
Immunodeficiency
Moderate:
Cervarix
The human papillomavirus vaccine in Cervarix has a moderate potential interaction with Immunodeficiency.
The expected serum antibody responses may not be obtained when vaccines and/or toxoids are administered to patients with primary or acquired immunodeficiency, including those with severe combined immunodeficiency, hypogammaglobulinemia or agammaglobulinemia, HIV infection, altered immune states (due to diseases such as leukemia, lymphoma, or generalized malignancy), or immunosuppression due to drug or other treatments (e.g., corticosteroids, alkylating agents, antimetabolites, or radiation).
Infection
Major:
Cervarix
The human papillomavirus vaccine in Cervarix has a major potential interaction with Infection.
Ideally, vaccination should occur when an individual is healthy, thus minimizing the risk of an adverse host reaction and/or vaccine failure. However, a current or recent infection does not necessarily preclude the use of vaccines, depending on the severity of the patient's symptoms and their etiology. Superficial infections and minor acute illnesses such as a mild upper respiratory infection with or without low-grade fever do not contraindicate immunization, particularly if prompt administration of a vaccine is deemed necessary or beneficial. In fact, when vaccines are administered during the course of a minor illness, the risk of adverse events is not increased, and serum antibody response is not often diminished. On the other hand, if fever or symptoms suggest a moderate or severe illness, it is usually appropriate to withhold vaccination until the patient has recovered. In addition to the potential risks already mentioned, evolving signs and symptoms of the illness can sometimes confound the diagnosis of a vaccine reaction if it develops. In the presence of any infection, the decision to administer or withhold/defer immunization should take into consideration the benefits versus the risks to an individual patient.
Moderate:
fruquintinib
Fruquintinib has a moderate potential interaction with Infection.
Infection was reported in patients taking fruquintinib. Fruquintinib should not be initiated in patients with active infections. Closely monitor for infection during treatment and withhold treatment during active infection.
Liver Disease
Moderate:
fruquintinib
Fruquintinib has a moderate potential interaction with Liver Disease.
Fruquintinib has not been evaluated in patients with moderate hepatic impairment (total bilirubin greater than 1.5 times and less than 3 times ULN and any AST) and it is not recommended for treatment in patients with severe hepatic impairment (total bilirubin greater than 3 times ULN and any AST).
Syncope
Moderate:
Cervarix
The human papillomavirus vaccine in Cervarix has a moderate potential interaction with Syncope.
The administration of human papillomavirus vaccine has been associated with syncope, sometimes resulting in falling with injury. The syncope sometimes is associated with tonic-clonic movements and other seizure-like activity. Caution is recommended when administering the vaccine to individuals susceptible to syncope. Observation for 15 minutes is recommended after its administration.
More resources
Cervarix
A total of 340 drugs are known to interact with Cervarix.
- Cervarix is in the drug class viral vaccines.
- Cervarix is used to treat Human Papillomavirus Prophylaxis.
fruquintinib
A total of 406 drugs are known to interact with fruquintinib.
- Fruquintinib is in the following drug classes: multikinase inhibitors, VEGF/VEGFR inhibitors.
- Fruquintinib is used to treat Colorectal Cancer.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.