Drug Interactions between cephalexin and cholera vaccine, live
This report displays the potential drug interactions for the following 2 drugs:
- cephalexin
- cholera vaccine, live
Interactions between your drugs
cephalexin cholera vaccine, live
Applies to: cephalexin and cholera vaccine, live
ADJUST DOSING INTERVAL: The use of live, attenuated cholera vaccine with systemic antibiotics may result in a diminished immunologic response to the vaccine. Some antibiotics may be active against the vaccine strain of Vibrio cholerae, thereby preventing a sufficient degree of multiplication to occur in order to induce a protective immune response.
MANAGEMENT: Live, attenuated cholera vaccine should not be administered during or for at least 14 days after treatment with systemic antibiotics.
References
- "Product Information. Vaxchora (cholera vaccine, live)." PaxVax (2016):
Drug and food interactions
cholera vaccine, live food
Applies to: cholera vaccine, live
ADJUST DOSING INTERVAL: There are no data regarding the concurrent administration of cholera oral vaccine with food or beverages.
MANAGEMENT: The manufacturer recommends that patients avoid eating or drinking for 60 minutes before and after administration of cholera oral vaccine.
References
- "Product Information. Vaxchora (cholera vaccine, live)." PaxVax (2016):
cephalexin food
Applies to: cephalexin
ADJUST DOSING INTERVAL: Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or cephradine. In one pharmacokinetic study (n=12), concurrent administration of zinc sulfate (250 mg, single oral dose) and cephalexin (500 mg, single oral dose) decreased cephalexin maximum concentration (Cmax) and systemic exposure (AUC; 0-inf) by 31.05% and 27.4%, respectively. However, in the same study, when zinc sulfate was administered 3 hours after the cephalexin dose, no significant alteration in cephalexin pharmacokinetics were observed.
MANAGEMENT: Oral medications or mineral supplements that contain zinc are recommended to be administered at least 3 hours after the cephalexin, ceftibuten or cephradine dose.
References
- Ding Y, Jia Y, Li F, et al. "The Effect of Staggered Administration of Zinc Sulfate on the Pharmacokinetics of Oral Cephalexin*" Br J Clin Pharmacol 73 (2011): 422-7
- World Health Organization "WHO Public Assessment Reports (WHOPARs) https://extranet.who.int/pqweb/medicines/prequalification-reports/whopars" (2020):
- Okamura M, Terada t, KatsuraT, Saito H, Inui K "Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2" Pharm Res 20 (2003): 1389-93
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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