Drug Interactions between Cepastat Sore Throat & Cough and Radiogardase

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

ADJUST DOSING INTERVAL: Food may enhance the effectiveness of Prussian blue insoluble by stimulating bile production and enterohepatic circulation, which increases the amount of cesium and thallium in the gastrointestinal lumen for binding with Prussian blue followed by elimination in the feces.

MONITOR: Prussian blue insoluble acts by ion exchange, adsorption, and mechanical trapping within its crystal structure. Theoretically, it may bind some orally administered therapeutic drugs.

MANAGEMENT: Prussian blue insoluble may be taken with food to stimulate excretion of cesium or thallium. As appropriate, blood levels of concomitantly administered oral medications and/or clinical response should be monitored, and the dosages adjusted as necessary.