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Drug Interactions between carbidopa and droxidopa

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

carbidopa droxidopa

Applies to: carbidopa and droxidopa

MONITOR: Coadministration with dopa-decarboxylase inhibitors such as carbidopa may reduce the therapeutic efficacy of droxidopa, which is directly metabolized in vivo to norepinephrine via decarboxylation. Droxidopa is believed to exert its pharmacological effects through norepinephrine and not through the parent molecule or other metabolites.

MANAGEMENT: Dosage adjustments for droxidopa may be required during coadministration with dopa-decarboxylase inhibitors if an interaction is suspected.

References (1)
  1. (2014) "Product Information. Northera (droxidopa)." Chelsea Therapeutics Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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