Drug Interactions between Calquence and Voxzogo

Acalabrutinib may be taken with or without food. However, consumption of grapefruit and grapefruit juice can increase the blood levels of acalabrutinib. This may increase side effects such as nausea, vomiting, diarrhea, abdominal pain, hemorrhage, development of other cancers, abnormal heart rhythm, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. You should avoid the consumption of grapefruit and grapefruit juice during treatment with acalabrutinib. Be sure to take the medication at approximately the same time(s) every day to maintain consistent blood levels and effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Vosoritide may cause transient decreases in blood pressure. To reduce the risk of low blood pressure and its associated symptoms, you should have adequate food intake before vosoritide administration and should drink approximately 8 to 10 ounces of liquids within the hour prior to vosoritide injection. Tell your doctor if you experience fatigue, nausea, dizziness, or lightheadedness after vosoritide injection. Avoid driving or operating hazardous machinery until you know how this medication affects you and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.