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Drug Interactions between calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate and K2 Plus D3

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate and K2 Plus D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate

A total of 346 drugs are known to interact with calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate.

K2 Plus D3

A total of 17 drugs are known to interact with K2 Plus D3.

Drug and food interactions

Major

sodium oxybate food

Applies to: calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate

CONTRAINDICATED: Alcohol may potentiate the central nervous system and respiratory depressant effects of sodium oxybate, which is the sodium salt of gamma hydroxybutyrate (GHB). An increased risk of serious adverse reactions such as respiratory depression, hypotension, profound sedation, syncope, coma, and even death should be anticipated.

ADJUST DOSING INTERVAL: Food may delay the absorption and significantly decrease the bioavailability of sodium oxybate. When sodium oxybate was administered immediately after a high-fat meal, the time to reach peak plasma concentration (Tmax) increased from 0.75 hour to 2 hours, the peak plasma concentration (Cmax) decreased by a mean of 59%, and the systemic exposure (AUC) decreased by a mean of 37%.

MANAGEMENT: The concomitant use of sodium oxybate with alcohol is considered contraindicated. The first dose of sodium oxybate should be taken at least 2 hours after a meal to ensure maximal absorption.

References (1)
  1. (2002) "Product Information. Xyrem (sodium oxybate)." Orphan Medical

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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