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Drug Interactions between bupivacaine and bupivacaine liposome

This report displays the potential drug interactions for the following 2 drugs:

  • bupivacaine
  • bupivacaine liposome

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Interactions between your drugs


bupivacaine bupivacaine liposome

Applies to: bupivacaine and bupivacaine liposome

Bupivacaine liposome is a specially formulated anesthetic that releases the medication into the surrounding tissue at a controlled rate. When exposed to other local anesthetic solutions, the release rate can be altered. Depending on the dose of bupivacaine relative to bupivacaine liposome, mixing these medications together or injecting them into the same area at the same time may cause rapid release of the active medication and alter the safety and efficacy of bupivacaine liposome. In general, additional use of local anesthetics including bupivacaine should be avoided within 96 hours following administration of bupivacaine liposome. If necessary, bupivacaine and bupivacaine liposome may be given simultaneously in the same syringe, or bupivacaine may be injected immediately before bupivacaine liposome, as long as the ratio of the milligram dose of bupivacaine to bupivacaine liposome does not exceed 1:2. However, because the toxic effects of these medications are additive, using them together requires caution and constant monitoring of vital signs and state of consciousness to prevent serious and potentially life-threatening side effects such as methemoglobinemia (a condition that can deprive tissues and organs of oxygen), central nervous system reactions (e.G., convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.G., low blood pressure, heart block, irregular heart rhythm, cardiac arrest). Patients require immediate medical attention if they develop signs and symptoms of methemoglobinemia such as pale, gray, or blue colored skin (cyanosis); headache; rapid heart rate; shortness of breath; lightheadedness; or fatigue.

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Drug and food interactions

No interactions were found. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.


Local injectable anesthetics

Therapeutic duplication

The recommended maximum number of medicines in the 'local injectable anesthetics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'local injectable anesthetics' category:

  • bupivacaine
  • bupivacaine liposome

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.