Can you take Brexanolone with Lemborexant?
1 drug interaction and 7 additional warnings found for the following 2 drugs:
- brexanolone
- lemborexant
Drug interactions
Major drug interactions
Major:
brexanolone lemborexant
Applies to: brexanolone and lemborexant
Brexanolone may cause excessive sedation and sudden loss of consciousness during the infusion. The risk and/or severity may be increased when combined with other antidepressants or other medications that can also cause sedation.
Let your doctor know prior to receiving brexanolone if you are currently using alcohol or receiving treatment with lemborexant, as you may be more likely to experience sedation-related side effects.
You should be under close medical supervision by a health care provider during administration of brexanolone. Tell your healthcare provider right away if you feel like you cannot stay awake during the time you are normally awake or if you feel like you are going to pass out. Your healthcare provider may lower your dose or stop the infusion until your symptoms go away.
You must have a caregiver or family member with you to help care for your child(ren) during your brexanolone infusion.
Do not drive, operate machinery, or engage in potentially hazardous activities requiring mental alertness and motor coordination until the sedative effects have gone away and you know how these medications affect you.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
lemborexant Food/Lifestyle
Applies to: lemborexant
Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with lemborexant unless directed otherwise by your doctor.
Grapefruit juice can increase the blood levels of lemborexant. This may increase the risk of side effects such as:
- central nervous system depression
- abnormal sleep behaviors
- worsening of depression or suicidal thoughts
- changes in heartbeat
- headache
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
6 potential interactions Applies to: 5 conditions, including Depression, Liver Disease, Alcoholism, Renal Dysfunction, and Pulmonary Impairment.
Alcoholism
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Alcoholism.
Patients treated with lemborexant should not consume alcohol as it can increase drowsiness and also the incidence of adverse effects.
Depression
Moderate:
brexanolone
Brexanolone has a moderate potential interaction with Depression.
Brexanolone is indicated for the treatment of postpartum depression. A placebo-controlled trial showed that patients with a previous diagnosis of major depressive disorder (MDD) had a higher incidence of suicidal thoughts and behaviors when treated with brexanolone. Consider changing the therapeutic regimen, including discontinuing brexanolone, in patients whose depression becomes worse or who experience emergent suicidal thoughts and behaviors.
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Depression.
Worsening of depression and suicidal thoughts and actions have been reported with the use of lemborexant. Caution is advised in patients with depression. Protective measures may be required in patients with suicidal tendencies, including prescription of the lowest number of tablets at one time.
Liver Disease
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Liver Disease.
Lemborexant has not been studied in patients with severe liver dysfunction (Child-Pugh Class C). Its use is not recommended in these patients.
Pulmonary Impairment
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Pulmonary Impairment.
Lemborexant has not been studied in patients with moderate to severe obstructive sleep apnea (OSA) or in patients with chronic obstructive pulmonary disease. Caution is advised if prescribing to patients with compromised respiratory function.
Renal Dysfunction
Major:
brexanolone
Brexanolone has a major potential interaction with Renal Dysfunction.
The effect of end stage renal disease (ESRD, eGFR < 15 mL/minute/1.73 m2) on brexanolone pharmacokinetics is unknown, and its use should be avoided in these patients because of the potential accumulation of the solubilizing agent, betadex sulfobutyl ether sodium. No dosage adjustment is recommended in patients with mild (eGFR 60 to 89 mL/minute/1.73 m2), moderate (eGFR 30 to 59 mL/minute/1.73 m2) or severe (eGFR 15 to 29 mL/minute/1.73 m2) renal impairment.
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More resources
brexanolone
A total of 276 drugs are known to interact with brexanolone.
- Brexanolone is in the drug class miscellaneous antidepressants.
- Brexanolone is used to treat Postpartum Depression.
lemborexant
A total of 490 drugs are known to interact with lemborexant.
- Lemborexant is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Lemborexant is used to treat Insomnia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.