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Drug Interactions between bosutinib and Caltrate 600 with Iron and Vitamin D

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

calcium carbonate ferrous fumarate

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d) and Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d)

By reducing the acidity level in the stomach, medications like calcium carbonate may interfere with the absorption of ferrous fumarate into the bloodstream and reduce its effectiveness. If you require treatment with both medications, it is recommended that you take ferrous fumarate at least 2 hours before or 2 hours after calcium carbonate to help minimize the impact of the interaction. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

calcium carbonate bosutinib

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d) and bosutinib

Bosutinib and calcium carbonate should not be taken orally at the same time. Products that can decrease acid levels in the stomach may interfere with the absorption of bosutinib and reduce its effectiveness. You should take calcium carbonate at least 2 hours before or 2 hours after the dose of bosutinib. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

calcium carbonate food

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d)

Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ferrous fumarate food

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d)

Food may reduce the absorption and blood levels of ferrous fumarate. In addition, some oral medications can also interfere with ferrous fumarate absorption into the bloodstream, which may make the medication less effective in treating your condition. Likewise, ferrous fumarate may interfere with the absorption of other orally administered medications. You should take ferrous fumarate on an empty stomach at least one hour before or two hours after a meal. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Talk to your doctor or pharmacist if you have questions about how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

bosutinib food

Applies to: bosutinib

Bosutinib should be taken with a meal to help with its absorption. Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with bosutinib unless directed otherwise by your doctor. Grapefruit juice can significantly increase the blood levels of bosutinib. You may be more likely to experience side effects such as nausea, vomiting, abdominal pain, diarrhea, liver damage, and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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