Skip to main content

Drug Interactions between Blue-Emu Maximum Strength Arthritis, Muscle & Joint Pain Relief and ibuprofen

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Minor

ibuprofen menthol topical

Applies to: ibuprofen and Blue-Emu Maximum Strength Arthritis, Muscle & Joint Pain Relief (menthol topical)

Coadministration with orally administered menthol may decrease plasma concentrations of drugs that are substrates of the CYP450 3A4 and/or CYP450 2C9 isoenzymes. The proposed mechanism is increased clearance due to menthol-mediated induction of CYP450 3A4 and CYP450 2C9. In vivo data suggests that concomitant administration of oral menthol reduced the systemic exposure (AUC) of triazolam (a CYP450 3A4 substrate) by 40%, and phenytoin (a CYP450 2C9 substrate) by 20%. Until further data are available, no specific precautions are recommended.

References (4)
  1. (2024) "Product Information. Advil Targeted Relief (camphor/capsicum/menthol/methyl salicylate topical)." Haleon
  2. Hoshino M (2015) "Effects of menthol on the pharmacokinetics of triazolam and phenytoin." Biol Pharm Bull, 38, p. 454-60
  3. Hoshino M (2014) "Menthol reduces the anticoagulation effect of warfarin by cytochrome p450 2C expression." Eur J Pharm Sci, 56, p. 92-101
  4. (2019) "Product Information. Radian B Muscle Rub (camphor/capsicum/menthol/meth salic top)." Thornton & Ross Ltd

Drug and food/lifestyle interactions

Moderate

ibuprofen food/lifestyle

Applies to: ibuprofen

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer