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Drug Interactions between Benemid and Cap-Profen

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

ibuprofen probenecid

Applies to: Cap-Profen (ibuprofen) and Benemid (probenecid)

Probenecid may interfere with the plasma protein binding, metabolism, and/or renal elimination of nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in increased NSAID plasma levels. The risk of NSAID toxicity may be increased. Although adverse effects from this interaction have not been reported, patients receiving this combination should be monitored for increased NSAID side effects. Patients should be advised to report possible signs of NSAID toxicity such as dizziness, drowsiness, headache, tinnitus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, or black tarry stools.

References

  1. Sinclair H, Gibson T "Interaction between probenecid and indomethacin." Br J Rheumatol 25 (1986): 316-7
  2. Upton RA, Williams RL, Buskin JN, Jones RM "Effects of probenecid in ketoprofen kinetics." Clin Pharmacol Ther 31 (1982): 705-12
  3. Foster RT, Jamali F, Russell AS "Pharmacokinetics of ketoprofen anentiomers in cholecystectomy patients: influence of probenecid." Eur J Clin Pharmacol 37 (1989): 589-94
  4. Brogden RN, Heel RC, Speight TM, Avery GS "Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states." Drugs 18 (1979): 241-77
  5. Runkel R, Mroszczak E, Chaplin M, et al. "Naproxen-probenecid interaction." Clin Pharmacol Ther 24 (1978): 706-13
  6. Diamond JS, Paolino JS "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest 52 (1973): 1491-9
  7. Mroszczak EJ, Combs DL, Goldblum R, et al. "The effect of probenecid on ketorolac pharmacokinetics after oral dosing of ketorolac tromethamine." Clin Pharmacol Ther 51 (1992): 154
  8. Macdonald JI, Wallace SM, Herman RJ, Verbeeck RK "Effect of propenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal." Eur J Clin Pharmacol 47 (1995): 519-23
View all 8 references

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Drug and food interactions

Moderate

ibuprofen food

Applies to: Cap-Profen (ibuprofen)

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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