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Drug interactions between Benadryl and Talwin Nx

Results for the following 2 drugs:
Benadryl (diphenhydramine)
Talwin Nx (naloxone/pentazocine)

Interactions between your drugs

Moderate

diphenhydrAMINE pentazocine

Applies to: Benadryl (diphenhydramine) and Talwin Nx (naloxone / pentazocine)

Using diphenhydrAMINE together with pentazocine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

pentazocine food

Applies to: Talwin Nx (naloxone / pentazocine)

Smoking tobacco may reduce the blood levels and effects of pentazocine. Contact your doctor if pentazocine is not adequately controlling your symptoms.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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