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Drug Interactions between astemizole and zileuton

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

astemizole zileuton

Applies to: astemizole and zileuton

GENERALLY AVOID: Zileuton is believed to be a weak inhibitor of cytochrome P450 3A4 enzymes, of which astemizole is a known substrate. Increased levels of astemizole may increase the potential for cardiotoxic effects, including life-threatening torsade de pointes.

MANAGEMENT: The coadministration of zileuton with astemizole should be avoided. Nonsedating antihistamines such as fexofenadine, loratadine, and cetirizine may be safer alternatives due to a lack of cardiotoxicity.

References (1)
  1. "Product Information. Zyflo (zileuton)." Abbott Pharmaceutical

Drug and food interactions

Major

astemizole food

Applies to: astemizole

GENERALLY AVOID: Some beverages such as tonic water contain varying amounts of quinine. Coadministration of a single 430 mg dose of quinine has been shown to increase plasma concentrations of astemizole and its metabolite, desmethylastemizole. Elevated levels of these agents may cause a prolongation of the electrocardiographic QT interval and potentially fatal ventricular arrhythmias. Although pharmacokinetic data have indicated that the amounts of quinine in beverages (up to 80 mg quinine in 32 oz of tonic water) are not sufficient to produce a significant effect, the potential for an interaction exists if large amounts of tonic water are ingested. Also, grapefruit juice has been shown to inhibit CYP450 enzymes, which may lead to increased serum astemizole concentrations. The risk of life-threatening ventricular arrhythmias may be increased.

MANAGEMENT: Patients should be counseled to limit consumption of quinine-containing beverages and avoid grapefruit juice while they are taking astemizole.

References (1)
  1. (2002) "Product Information. Hismanal (astemizole)." Janssen Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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