Drug Interactions between astemizole and Morning SickLess
This report displays the potential drug interactions for the following 2 drugs:
- astemizole
- Morning SickLess (ginger/magnesium sulfate/pyridoxine)
Interactions between your drugs
No interactions were found between astemizole and Morning SickLess. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
astemizole
A total of 345 drugs are known to interact with astemizole.
- Astemizole is in the drug class antihistamines.
- Astemizole is used to treat Allergies.
Morning SickLess
A total of 191 drugs are known to interact with Morning SickLess.
- Morning sickless is in the drug class vitamin and mineral combinations.
- Morning sickless is used to treat Nausea/Vomiting of Pregnancy.
Drug and food interactions
astemizole food
Applies to: astemizole
GENERALLY AVOID: Some beverages such as tonic water contain varying amounts of quinine. Coadministration of a single 430 mg dose of quinine has been shown to increase plasma concentrations of astemizole and its metabolite, desmethylastemizole. Elevated levels of these agents may cause a prolongation of the electrocardiographic QT interval and potentially fatal ventricular arrhythmias. Although pharmacokinetic data have indicated that the amounts of quinine in beverages (up to 80 mg quinine in 32 oz of tonic water) are not sufficient to produce a significant effect, the potential for an interaction exists if large amounts of tonic water are ingested. Also, grapefruit juice has been shown to inhibit CYP450 enzymes, which may lead to increased serum astemizole concentrations. The risk of life-threatening ventricular arrhythmias may be increased.
MANAGEMENT: Patients should be counseled to limit consumption of quinine-containing beverages and avoid grapefruit juice while they are taking astemizole.
References
- (2002) "Product Information. Hismanal (astemizole)." Janssen Pharmaceuticals
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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