Drug Interactions between Astagraf XL and benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate
This report displays the potential drug interactions for the following 2 drugs:
- Astagraf XL (tacrolimus)
- benzoic acid/hyoscyamine/methenamine/methylene blue/phenyl salicylate
Interactions between your drugs
No interactions were found between Astagraf XL and benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Astagraf XL
A total of 834 drugs are known to interact with Astagraf XL.
- Astagraf xl is in the drug class calcineurin inhibitors.
- Astagraf xl is used to treat Organ Transplant, Rejection Prophylaxis.
benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate
A total of 572 drugs are known to interact with benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate.
- Benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate is in the drug class urinary antispasmodics.
- Benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate is used to treat Urinary Tract Infection.
Drug and food interactions
tacrolimus food
Applies to: Astagraf XL (tacrolimus)
ADJUST DOSING INTERVAL: Consumption of food has led to a 27% decrease in the bioavailability of orally administered tacrolimus.
MANAGEMENT: Tacrolimus should be administered at least one hour before or two hours after meals.
GENERALLY AVOID: Grapefruit juice has been reported to increase tacrolimus trough concentrations. Data are limited, but inhibition of the CYP450 enzyme system appears to be involved.
MANAGEMENT: The clinician may want to recommend that the patient avoid ingesting large amounts of grapefruit juice while taking tacrolimus.
References
- "Product Information. Prograf (tacrolimus)." Fujisawa PROD (2001):
- Hooks MA "Tacrolimus, a new immunosuppressant--a review of the literature." Ann Pharmacother 28 (1994): 501-11
hyoscyamine food
Applies to: benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate
GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
References
- Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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