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Drug Interactions between aspirin / caffeine / orphenadrine and Depakote

This report displays the potential drug interactions for the following 2 drugs:

  • aspirin/caffeine/orphenadrine
  • Depakote (divalproex sodium)

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Interactions between your drugs

Moderate

aspirin divalproex sodium

Applies to: aspirin / caffeine / orphenadrine and Depakote (divalproex sodium)

Before taking aspirin, tell your doctor if you also use divalproex sodium. You may need dose adjustments or special tests in order to safely take both medications together. Small single doses of aspirin are unlikely to cause significant effects. However, if you take aspirin over a prolonged period of time you may need your divalproex sodium levels checked. You should notify your doctor if you have symptoms of fever, weakness, drowsiness, nausea, vomiting, or stomach pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

orphenadrine divalproex sodium

Applies to: aspirin / caffeine / orphenadrine and Depakote (divalproex sodium)

Using orphenadrine together with divalproex sodium may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

aspirin caffeine

Applies to: aspirin / caffeine / orphenadrine and aspirin / caffeine / orphenadrine

Information for this minor interaction is only available at a professional reading level.

For clinical details see professional interaction data.

Drug and food interactions

Moderate

orphenadrine food

Applies to: aspirin / caffeine / orphenadrine

Alcohol can increase the nervous system side effects of orphenadrine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with orphenadrine. Do not use more than the recommended dose of orphenadrine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

divalproex sodium food

Applies to: Depakote (divalproex sodium)

Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with divalproex sodium. Do not use more than the recommended dose of divalproex sodium, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Minor

caffeine food

Applies to: aspirin / caffeine / orphenadrine

Information for this minor interaction is only available at a professional reading level.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.