Drug Interactions between asciminib and epirubicin

MONITOR: Coadministration with asciminib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. In vitro, asciminib is a substrate and inhibitor of P-gp, an efflux transporter expressed in the gastrointestinal tract, liver, and kidney. However, drug interaction studies with P-gp substrates have not been conducted.

MANAGEMENT: Caution is advised when asciminib is used concomitantly with drugs that are substrates of P-gp, particularly sensitive substrates or those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever asciminib is added to or withdrawn from therapy. The prescribing information recommends closely monitoring for the development of adverse reactions in patients receiving asciminib therapy with certain P-gp substrates where minimal concentration changes may lead to serious or life-threatening toxicities. In addition, the prescribing information for concomitant medications should be consulted to assess the benefits versus risks of coadministration of a P-gp inhibitor like asciminib and for any dosage adjustments that may be required.