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Drug Interactions between aminosalicylic acid and Crystamine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cyanocobalamin aminosalicylic acid

Applies to: Crystamine (cyanocobalamin) and aminosalicylic acid

MONITOR: Limited data suggest that aminosalicylic acid may decrease the gastrointestinal absorption of vitamin B12. Coadministration of aminosalicylic acid 5 g orally has been reported to reduce the absorption of vitamin B12 by 55%. Clinically significant erythrocyte abnormalities have been reported; however, the body (primarily the liver) usually has a copious supply of vitamin B12 that can sustain a person for several years in the absence of adequate intake.

MANAGEMENT: Due to the potential for reduced vitamin B12 absorption, the manufacturer recommends that maintenance vitamin B12 be considered in patients on aminosalicylic acid therapy for longer than one month. As for the treatment of B12 deficiency-related anemia, non-oral routes of administration (e.g., parenteral, intranasal, sublingual) are generally preferred, which would bypass the potential interaction.

References

  1. Halsted CH, McIntyre PA "Intestinal malabsorption caused by aminosalicylic acid therapy." Arch Intern Med 130 (1972): 935-9
  2. Palva IP, Rytkonen U, Slatulkkila M, Palva M "Drug-induced malabsorption of vitamin B12." Scand J Haematol 9 (1972): 5-7
  3. Heinivaara O "Malabsorption of vitamin B112 during treatment with para-aminosalicylic acid: a preliminary report." Acta Med Scand 175 (1964): 469-71
  4. Levine RA, "Steatorrhea induced by para-aminosalicylic acid." Ann Intern Med 68 (1968): 1265
  5. "Product Information. Paser D/R (aminosalicylic acid)." Jacobus Pharmaceutical Company
View all 5 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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