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Drug Interactions between amantadine and Bactrim

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

amantadine trimethoprim

Applies to: amantadine and Bactrim (sulfamethoxazole / trimethoprim)

MONITOR: Trimethoprim may decrease the renal clearance of amantadine and memantine. The mechanism may be competition for organic cation transporter-2 (OCT-2)-mediated secretion in the kidney tubule of which amantadine, memantine, and trimethoprim are substrates. Trimethoprim may also inhibit OCT-2. Increased levels of amantadine and memantine may increase the risk of neurological side effects such as mental confusion, delirium, and myoclonus. Serum trimethoprim levels may also be increased.

MANAGEMENT: Caution and monitoring for nervous system side effects is recommended if trimethoprim is used with either amantadine or memantine. Patients should be advised to contact their physician if they experience nervous system side effects such as mental confusion and myoclonus.

References (5)
  1. Speeg KV, Leighton JA, Maldonado AL (1989) "Case report: toxic delirium in a patient taking amantadine and trimethoprim sulfamethoxazole." Am J Med Sci, 298, p. 410-2
  2. (2022) "Product Information. Bactrim (sulfamethoxazole-trimethoprim)." Roche Laboratories
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  4. Cerner Multum, Inc. "Australian Product Information."
  5. Moellentin D, Picone C, Leadbetter E (2008) "Memantine-induced myoclonus and delirium exacerbated by trimethoprim." Ann Pharmacother, 42, p. 449-7

Drug and food interactions

Moderate

sulfamethoxazole food

Applies to: Bactrim (sulfamethoxazole / trimethoprim)

MONITOR: Two cases have been reported in which patients on sulfamethoxazole-trimethoprim therapy, after consuming beer, reported flushing, heart palpitations, dyspnea, headache, and nausea (disulfiram - alcohol type reactions). First-generation sulfonylureas have been reported to cause facial flushing when administered with alcohol by inhibiting acetaldehyde dehydrogenase and subsequently causing acetaldehyde accumulation. Since sulfamethoxazole is chemically related to first-generation sulfonylureas, a disulfiram-like reaction with products containing sulfamethoxazole is theoretically possible. However, pharmacokinetic/pharmacodynamic data are lacking and in addition, the two reported cases cannot be clearly attributed to the concomitant use of sulfamethoxazole-trimethoprim and alcohol.

MANAGEMENT: Patients should be alerted to the potential for this interaction and although the risk for this interaction is minimal, caution is recommended while taking sulfamethoxazole-trimethoprim concomitantly with alcohol.

References (2)
  1. Heelon MW, White M (1998) "Disulfiram-cotrimoxazole reaction." Pharmacotherapy, 18, p. 869-70
  2. Mergenhagen KA, Wattengel BA, Skelly MK, Clark CM, Russo TA (2020) "Fact versus fiction: a review of the evidence behind alcohol and antibiotic interactions." Antimicrob Agents Chemother, 64, e02167-19

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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