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Drug Interactions between aldesleukin and budesonide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

aldesleukin budesonide

Applies to: aldesleukin and budesonide

GENERALLY AVOID: Glucocorticoids may antagonize the immunoregulatory properties of aldesleukin and reduce its antitumor effectiveness.

MANAGEMENT: Although glucocorticoids can attenuate aldesleukin-induced side effects including fever, renal insufficiency, hyperbilirubinemia, confusion and dyspnea, concomitant administration of these agents with aldesleukin should generally be avoided. However, patients who develop life-threatening signs or symptoms may be treated with dexamethasone until toxicity resolves to an acceptable level.

References (1)
  1. (2001) "Product Information. Proleukin (aldesleukin)." Chiron Therapeutics

Drug and food interactions

Moderate

budesonide food

Applies to: budesonide

GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations and systemic effects of orally administered budesonide. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. According to the manufacturer, the systemic exposure of oral budesonide approximately doubles after extensive intake of grapefruit juice.

MANAGEMENT: Patients receiving budesonide should avoid the regular consumption of grapefruits and grapefruit juice to prevent undue increases in plasma budesonide levels and systemic effects.

References (1)
  1. (2001) "Product Information. Entocort (budesonide)." AstraZeneca Pharma Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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