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Drug Interactions between Afinitor and amoxicillin / clarithromycin / vonoprazan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

clarithromycin everolimus

Applies to: amoxicillin / clarithromycin / vonoprazan and Afinitor (everolimus)

Using everolimus together with clarithromycin is not recommended. Combining these medications can significantly increase the blood levels of everolimus, which may make you more likely to develop serious side effects such as pneumonitis (inflammation of the lungs), infection, mouth ulcers, anemia, or bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

everolimus vonoprazan

Applies to: Afinitor (everolimus) and amoxicillin / clarithromycin / vonoprazan

Vonoprazan may increase the blood levels of everolimus. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience new or worsening side effects of everolimus such as mouth ulcers, fever, infection, shortness of breath, diarrhea, dizziness, paleness, fainting, and/or unusual bleeding or bruising while taking these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

amoxicillin clarithromycin

Applies to: amoxicillin / clarithromycin / vonoprazan and amoxicillin / clarithromycin / vonoprazan

Information for this minor interaction is available on the professional version.

Drug and food interactions

Moderate

everolimus food

Applies to: Afinitor (everolimus)

Grapefruit juice can increase the blood levels and effects of everolimus. You should not drink grapefruit juice or eat grapefruits during your treatment with everolimus. Orange juice is not expected to interact.

Minor

clarithromycin food

Applies to: amoxicillin / clarithromycin / vonoprazan

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer