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Drug Interactions between Adderall XR and esketamine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

amphetamine esketamine

Applies to: Adderall XR (amphetamine / dextroamphetamine) and esketamine

Esketamine can cause transient but significant increases in blood pressure, and using it with amphetamine may increase the risk. Let your doctor know if you have been using amphetamine prior to getting treatment with esketamine. You may need a dose adjustment or more frequent monitoring of your blood pressure to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Major

dextroamphetamine esketamine

Applies to: Adderall XR (amphetamine / dextroamphetamine) and esketamine

Esketamine can cause transient but significant increases in blood pressure, and using it with dextroamphetamine may increase the risk. Let your doctor know if you have been using dextroamphetamine prior to getting treatment with esketamine. You may need a dose adjustment or more frequent monitoring of your blood pressure to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

amphetamine food

Applies to: Adderall XR (amphetamine / dextroamphetamine)

Using amphetamine together with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. You should avoid or limit the use of alcohol while being treated with amphetamine. Let your doctor know if you experience severe or frequent headaches, chest pain, and/or a fast or pounding heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

dextroamphetamine food

Applies to: Adderall XR (amphetamine / dextroamphetamine)

Using dextroamphetamine together with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. You should avoid or limit the use of alcohol while being treated with dextroamphetamine. Let your doctor know if you experience severe or frequent headaches, chest pain, and/or a fast or pounding heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

esketamine food

Applies to: esketamine

Using esketamine together with alcohol may increase side effects such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. You should avoid or limit the use of alcohol while being treated with esketamine. Nausea and vomiting may occur following the nasal application of esketamine. To help prevent nausea and vomiting, you should avoid eating for at least 2 hours before using esketamine and avoid drinking liquids for at least 30 minutes before using esketamine.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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