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Drug Interactions between Adcetris and bleomycin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

bleomycin brentuximab vedotin

Applies to: bleomycin and Adcetris (brentuximab)

CONTRAINDICATED: Coadministration of brentuximab with bleomycin may increase the risk of pulmonary toxicity. The mechanism has not been described. In a clinical trial that involved use of the two agents as part of a combination regimen, the rate of noninfectious pulmonary toxicity was higher than the historical incidence reported with ABVD (adriamycin, bleomycin, vinblastine, dacarbazine). Patients typically reported cough and dyspnea. Interstitial infiltration and/or inflammation were observed on radiographs and computed tomographic imaging of the chest. Most patients responded to corticosteroids.

MANAGEMENT: Concomitant use of brentuximab and bleomycin is considered contraindicated.

References (1)
  1. (2011) "Product Information. Adcetris (brentuximab vedotin)." Seattle Genetics Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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