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Drug Interactions between Actigall and colesevelam

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

ursodiol colesevelam

Applies to: Actigall (ursodiol) and colesevelam

ADJUST DOSING INTERVAL: Bile acid sequestering agents may bind ursodiol (ursodeoxycholic acid) in the intestine, potentially reducing its absorption and efficacy.

MANAGEMENT: Ursodiol should not be administered simultaneously with a bile acid sequestering agent. The prescribing information for colesevelam recommends taking concomitant oral medications at least 4 hours before colesevelam. For concomitant medications that require administration via divided doses, it should be noted that the required dose of colesevelam may be given once a day. Additional monitoring of clinical effects may be considered in patients requiring combination therapy and appropriate adjustments made if clinically necessary.

References (8)
  1. (2024) "Product Information. Colesevelam Hydrochloride (colesevelam)." Ascend Laboratories, LLC
  2. (2024) "Product Information. Colesevelam (colesevelam)." Dr Reddy's Laboratories (UK) Ltd
  3. (2020) "Product Information. Lodalis (colesevelam)." Bausch & Lomb Canada Inc
  4. (2024) "Product Information. Ursodiol (ursodiol)." Watson Pharmaceuticals
  5. (2023) "Product Information. Ursodeoxycholic Acid (ursodeoxycholic acid)." Advanz Pharma
  6. (2024) "Product Information. Ursodox (GH) (ursodeoxycholic acid)." Lupin Australia Pty Ltd
  7. (2023) "Product Information. NRA-Ursodiol (ursodiol)." Nora Pharma Inc
  8. (2021) "Product Information. CHOLESTAGEL (colesevelam)." Cheplapharm Arzneimittel GmbH

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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