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Drug Interactions between acoramidis and diclofenac

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

diclofenac acoramidis

Applies to: diclofenac and acoramidis

MONITOR: Coadministration with acoramidis may increase the plasma concentrations of drugs that are substrates of the CYP450 2C9 isoenzyme. In vitro data show that acoramidis is a time-dependent inhibitor of CYP450 2C9. The proposed mechanism is decreased clearance due to inhibition of the isoenzyme by acoramidis.

MANAGEMENT: Caution is advised when acoramidis is used concomitantly with drugs that undergo metabolism by CYP450 2C9, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever acoramidis is added to or withdrawn from therapy.

References (1)
  1. (2024) "Product Information. Attruby (acoramidis)." BridgeBio Pharma, Inc

Drug and food interactions

Moderate

diclofenac food

Applies to: diclofenac

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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