Drug Interactions between Aciphex Sprinkle and crizotinib
This report displays the potential drug interactions for the following 2 drugs:
- Aciphex Sprinkle (rabeprazole)
- crizotinib
Interactions between your drugs
No interactions were found between Aciphex Sprinkle and crizotinib. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Aciphex Sprinkle
A total of 166 drugs are known to interact with Aciphex Sprinkle.
- Aciphex sprinkle is used to treat GERD.
crizotinib
A total of 771 drugs are known to interact with crizotinib.
- Crizotinib is in the drug class multikinase inhibitors.
- Crizotinib is used to treat the following conditions:
Drug and food interactions
crizotinib food
Applies to: crizotinib
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of crizotinib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Because crizotinib is associated with concentration-dependent prolongation of the QT interval, increased levels may potentiate the risk of ventricular arrhythmias such as torsade de pointes and sudden death.
Food has no significant effect on the gastrointestinal absorption of crizotinib. According to the product labeling, a high-fat meal reduced crizotinib peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 14%.
MANAGEMENT: Patients treated with crizotinib should avoid consumption of grapefruit, grapefruit juice, and any supplement containing grapefruit extract. Crizotinib may be taken without regards to food.
References
- "Product Information. Xalkori (crizotinib)." Pfizer U.S. Pharmaceuticals Group (2011):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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