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Drug Interactions between Accutane and Mirena

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

levonorgestrel ISOtretinoin

Applies to: Mirena (levonorgestrel) and Accutane (isotretinoin)

Using ISOtretinoin and levonorgestrel is not recommended. ISOtretinoin can cause severe, life-threatening birth defects if the mother takes the medication during pregnancy. Even one dose of ISOtretinoin can cause major birth defects of the baby's ears, eyes, face, skull, heart, and brain. Never use ISOtretinoin if you are pregnant. You must agree in writing to use two specific forms of birth control beginning 30 days before you start taking ISOtretinoin and ending 30 days after you stop taking it. Both a primary and a secondary form of birth control must be used together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

levonorgestrel food

Applies to: Mirena (levonorgestrel)

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with levonorgestrel. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Moderate

ISOtretinoin food

Applies to: Accutane (isotretinoin)

Ask your doctor before using ISOtretinoin together with ethanol. Do not drink alcohol while you are taking ISOtretinoin. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Check your food and medicine labels to be sure these products do not contain alcohol. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

levonorgestrel food

Applies to: Mirena (levonorgestrel)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.