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Drug Interactions between Abatron AF and Syprine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

trientine multivitamin with iron

Applies to: Syprine (trientine) and Abatron AF (multivitamin with iron)

ADJUST DOSING INTERVAL: The oral bioavailability of trientine and iron or other minerals may be decreased during concurrent administration. The proposed mechanism is chelation of trientine by polyvalent cations, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract.

MANAGEMENT: In general, mineral supplements and other products containing minerals should not be used in patients treated with trientine. However, iron deficiency may develop, particularly in children and menstruating or pregnant women. If necessary, iron may be given in short courses, provided that administration times are separated by at least two hours.

References

  1. "Product Information. Syprine (trientine)." Aton Pharma PROD (2001):

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Drug and food interactions

Moderate

trientine food

Applies to: Syprine (trientine)

ADJUST DOSING INTERVAL: The gastrointestinal absorption of trientine may be decreased in the presence of food, resulting in reduced therapeutic effects.

MANAGEMENT: Trientine should be administered on an empty stomach, at least one hour before or two hours after meals and at least one hour apart from any other food, drug, or milk.

References

  1. "Product Information. Syprine (trientine)." Aton Pharma PROD (2001):

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Moderate

multivitamin with iron food

Applies to: Abatron AF (multivitamin with iron)

ADJUST DOSING INTERVAL: Concomitant use of some oral medications may reduce the bioavailability of orally administered iron, and vice versa.

Food taken in conjunction with oral iron supplements may reduce the bioavailability of the iron. However, in many patients intolerable gastrointestinal side effects occur necessitating administration with food.

MANAGEMENT: Ideally, iron products should be taken on an empty stomach (i.e., at least 1 hour before or 2 hours after meals), but if this is not possible, administer with meals and monitor the patient more closely for a subtherapeutic effect. Some studies suggest administration of iron with ascorbic acid may enhance bioavailability. In addition, administration of oral iron products and some oral medications should be separated whenever the bioavailability of either agent may be decreased. Consult the product labeling for specific separation times and monitor clinical responses as appropriate.

References

  1. "Product Information. Feosol (ferrous sulfate)." SmithKline Beecham PROD
  2. "Product Information. Accrufer (ferric maltol)." Shield Therapeutics (2021):

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Moderate

trientine food

Applies to: Syprine (trientine)

GENERALLY AVOID: Concurrent oral administration of mineral supplements or mineral-containing products may block the absorption of trientine, and vice versa. The mechanism is trientine chelation of polyvalent metal ions resulting in a nonabsorbable complex.

MANAGEMENT: In general, mineral supplements or mineral-containing products (e.g., antacids) should not be used in patients treated with trientine. If concomitant use is unavoidable, separation of administration times by at least two hours is advisable.

References

  1. "Product Information. Syprine (trientine)." Aton Pharma PROD (2001):
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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