Priorix Dosage

Dose and Schedule

After reconstitution, a single dose of PRIORIX is approximately 0.5 mL.

Administer according to the following schedule:

•

First dose – 12 through 15 months of age

•

Second dose – 4 through 6 years of age

If PRIORIX is not administered according to this schedule and 2 doses of measles-, mumps- and rubella-virus vaccine are recommended for an individual, there should be a minimum of 4 weeks between the first and second dose.

PRIORIX may be administered as a second dose to individuals who have received a first dose of another measles, mumps and rubella virus-containing vaccine.

Preparation

Reconstitute the Lyophilized Antigen Component, Live only with the accompanying Sterile Water Diluent Component to form PRIORIX. The reconstituted vaccine should be a clear peach- to fuchsia pink-colored suspension. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If either of these conditions exists, do not administer the vaccine.

Figure 1. Hold the prefilled syringe by the barrel and unscrew the syringe cap by twisting it counterclockwise. Align the needle to the axis of the syringe and attach by gently connecting the needle hub into the Luer Lock Adaptor (LLA) and rotate a quarter turn clockwise until you feel it lock.	Figure 2. Cleanse the vial stopper. Transfer the entire contents of the prefilled syringe into the lyophilized antigen component vial.	Figure 3. Shake the vial well until the powder is completely dissolved. Do not invert the vial while shaking.	Figure 4. After reconstitution, withdraw the entire contents of the reconstituted vaccine into the same syringe and after changing the needle, administer subcutaneously.

Administration

Administer PRIORIX immediately after reconstitution. If not used immediately, store refrigerated between 36° and 46° F (2° and 8°C) and administer within 8 hours. Discard reconstituted vaccine if not used within 8 hours.