Prademagene Zamikeracel Topical Dosage

Medically reviewed by Drugs.com. Last updated on Jul 22, 2025.

Usual Adult Dose for Epidermolysis Bullosa

Apply one to twelve sheets topically depending on wound size

Comments:

• One sheet of this drug covers an area of 41.25 cm2.
• Verify patient's identity during preparation.
• Hold this drug at room temperature (15C to 25C) until application.
• Apply the appropriate sheets in a single surgical session.
• Do not trim the sheets.
• Cover area of application with non-adhesive dressings and topical antibiotic ointment.
• Advise the patient to leave the treated area undisturbed for 5 to 10 days based on clinical judgement.
• Advise patient to keep dressings dry and to not submerge in water until the gauze of the product falls off the treatment site. The backing should fall off within 2 to 3 weeks of application.

Use: Treatment of wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB).

Usual Pediatric Dose for Epidermolysis Bullosa

Apply one to twelve sheets topically depending on wound size

Comments:

• One sheet of this drug covers an area of 41.25 cm2.
• Verify patient's identity during preparation.
• Hold this drug at room temperature (15C to 25C) until application.
• Apply the appropriate sheets in a single surgical session.
• Do not trim the sheets.
• Cover area of application with non-adhesive dressings and topical antibiotic ointment.
• Advise the patient to leave the treated area undisturbed for 5 to 10 days based on clinical judgement.
• Advise patient to keep dressings dry and to not submerge in water until the gauze of the product falls off the treatment site. The backing should fall off within 2 to 3 weeks of application.

Use: Treatment of wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB).

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• The manufacturer product information should be consulted.
• Verify patient's identity during preparation.
• Apply the appropriate sheets in a single surgical session.
• Do not trim the sheets.
• Cover area of application with non-adhesive dressings and topical antibiotic ointment.
• Advise the patient to leave the treated area undisturbed for 5 to 10 days based on clinical judgement.
• Advise patient to keep dressings dry and to not submerge in water until the gauze of the product falls off the treatment site. The backing should fall off within 2 to 3 weeks of application.

Storage requirements:

• Room temperature (15C to 25C) for up to 84 hours

Preparation techniques:

• The manufacturer product information should be consulted.

Patient advice:

• Leave the treated area undisturbed for 5 to 10 days or the length of time your provider has told you.
• Keep dressings dry and do not submerge in water until the gauze of the product falls off the treatment site. The backing should fall off within 2 to 3 weeks of application.
• Seek immediate medical help if any signs or symptoms of a hypersensitivity reaction occur, such as itching, swelling, hives, difficulty breathing, runny nose, watery eyes, nausea, and in severe cases, anaphylaxis.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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