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Korsuva Dosage

Generic name: DIFELIKEFALIN ACETATE 50ug in 1mL
Dosage form: injection, solution
Drug class: Peripheral opioid receptor agonists

Medically reviewed by Last updated on Dec 15, 2021.


The recommended dosage of KORSUVA is 0.5 mcg/kg administered by intravenous bolus injection into the venous line of the dialysis circuit at the end of each HD treatment [see Dosage and Administration (2.3)].
If a regularly scheduled HD treatment is missed, resume KORSUVA at the end of the next HD treatment.

Preparation Instructions

Do not mix or dilute KORSUVA prior to administration.
Inspect KORSUVA for particulate matter and discoloration prior to administration. The solution should be clear and colorless. Do not use KORSUVA vials if particulate matter or discoloration is observed.
KORSUVA is supplied in a single-dose vial. Discard any unused product.
Injection volume to be administered is determined by patient’s target dry body weight in kilograms (one patient may use less than the full contents of the vial or use more than one vial). See Table 1.
Table 1. KORSUVA Injection Volumes Based on Target Dry Body Weight
Total Injection Volume (mL) = Patient Target Dry Body Weight (kg) x 0.01, rounded to the nearest tenth (0.1 mL). For patient target dry body weight outside of the ranges in Table 1, use this formula.

Target Dry Body Weight Range (kg)

Injection Volume (mL)*

36 – 44


45 ‒ 54


55 – 64


65 – 74


75 – 84


85 – 94


95 – 104


105 – 114


115 – 124


125 – 134


135 – 144


145 – 154


155 – 164


165 – 174


175 – 184


185 – 194


195 – 204


Administration Instructions

KORSUVA is removed by the dialyzer membrane and must be administered after blood is no longer circulating through the dialyzer.
Administer KORSUVA by intravenous bolus injection into the venous line of the dialysis circuit at the end of each HD session.
The dose may be given either during or after rinse back of the dialysis circuit.
If the dose is given after rinse back, administer KORSUVA into the venous line followed by at least 10 mL of normal saline flush.
If the dose is given during rinse back, no additional normal saline is needed to flush the line.
The dose must be administered within 60 minutes of the completion of the syringe preparation. Discard any unused product.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.