Ekterly Dosage
Generic name: Sebetralstat 300mg
Dosage form: tablet
Medically reviewed by Drugs.com. Last updated on Jul 7, 2025.
Recommended Dosage
The recommended dosage of EKTERLY is one dose of 600 mg (two tablets) orally at the earliest recognition of an acute HAE attack.
- A second dose of 600 mg (two tablets) may be taken at least 3 hours after the first dose if response is inadequate, or if symptoms worsen or recur.
- Maximum recommended dosage is 1,200 mg (four tablets) in any 24-hour period.
2.2 Dosage Modification for CYP3A4 Inhibitors and Inducers
Refer to Table 1 for dosage modification of EKTERLY when used concomitantly with CYP3A4 inhibitors and inducers.
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Dosage Modification for Concomitant use of EKTERLY with CYP3A4 Inhibitors |
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Strong CYP3A4 Inhibitors |
Avoid concomitant use with EKTERLY. |
|
Moderate CYP3A4 Inhibitors |
Reduce EKTERLY dosage to 300 mg (one tablet) orally at earliest recognition of an acute HAE attack. A second dose of 300 mg (one tablet) may be taken at least 3 hours after first dose if response is inadequate or if symptoms worsen or recur. |
|
Weak CYP3A4 Inhibitors |
No dosage modification of EKTERLY. |
|
Dosage Modification for Concomitant use of EKTERLY with CYP3A4 Inducers |
|
|
Strong and Moderate CYP3A4 Inducers |
Avoid concomitant use with EKTERLY. |
|
Weak CYP3A4 Inducers |
No dosage modification of EKTERLY. |
Recommended Dosage in Patients with Hepatic Impairment
Refer to Table 2 for recommended dosage of EKTERLY in patients with hepatic impairment.
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Recommended Dosage of EKTERLY in Patients with Hepatic Impairment |
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Severe Hepatic Impairment (Child-Pugh Class C) |
Avoid use of EKTERLY. |
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Moderate Hepatic Impairment (Child-Pugh Class B) |
Recommended dosage of EKTERLY is one dose of 300 mg (one tablet) orally at the earliest recognition of an acute HAE attack. A second dose of 300 mg (one tablet) may be taken at least 3 hours after the first dose if response is inadequate, or if symptoms worsen or recur. |
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Mild Hepatic Impairment (Child-Pugh Class A) |
Recommended dosage is the same as the recommended dosage in patients with normal hepatic function. |
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