Skip to Content

E-Max-1000 (vitamin e) Disease Interactions

There are 2 disease interactions with E-Max-1000 (vitamin e):


Vitamin E (applies to E-Max-1000) hepatobiliary dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease, Biliary Obstruction

Vitamin E is fat soluble and many oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin E. Water- miscible vitamin E formulations may be better absorbed from the GI tract under these conditions. Vitamin E is metabolized by the liver and primarily excreted in bile and feces. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of vitamin E.


  1. "Product Information. Aquasol E (vitamin E)." Astra USA, Westborough, MA.

Vitamin E (applies to E-Max-1000) malabsorption syndromes

Minor Potential Hazard, High plausibility.

Vitamin E is readily absorbed from the intestinal tract in the presence of bile. Prolonged fat malabsorption (cystic fibrosis, hepatic cirrhosis, sprue) or malabsorption syndromes (celiac disease, GI resection) can decrease the absorption of many oral formulations of vitamin E. A water- miscible formulation of vitamin E may be better absorbed in these conditions.


  1. "Product Information. Epinephrine Hydrochloride Injection (epinephrine)." Abbott Pharmaceutical, Abbott Park, IL.
  2. Kubota Y, Toyoda Y, Kubota H, Asada A "Epinephrine in local anesthetics does indeed produce hypokalemia and ECG changes." Anesth Analg 77 (1993): 867-8
  3. Caruso M, Orszulak TA, Miles JM "Lactic acidosis and insulin resistance associated with epinephrine administration in a patient with non-insulin-dependent diabetes mellitus." Arch Intern Med 147 (1987): 1422-4
  4. Guerin JM, Meyer P, Habib Y "Is there a direct relationship between lactic acidosis and epinephrine administration?." Arch Intern Med 148 (1988): 980-1
  5. "Product Information. Adrenalin Chloride Solution (epinephrine)." Parke-Davis, Morris Plains, NJ.
  6. Cardon PV, Weiss JL, Mueller PS "Effects of small intravenous doses of epinephrine on serum insulin, glucose tolerance and serum free fatty acids." Diabetes 23 (1974): 743-7
  7. Panacek EA, Sherman B "Lactic acidosis and insulin resistance associated with epinephrine in a patient with noninsulin-dependent diabetes mellitus." Arch Intern Med 148 (1988): 1879
  8. "Product Information. Aquasol E (vitamin E)." Astra USA, Westborough, MA.
View all 8 references

E-Max-1000 (vitamin e) drug interactions

There are 209 drug interactions with E-Max-1000 (vitamin e)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.