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Arfonad (trimethaphan camsylate) Disease Interactions

There are 3 disease interactions with Arfonad (trimethaphan camsylate):

Major

Trimethaphan (applies to Arfonad) hypotension

Major Potential Hazard, High plausibility. Applicable conditions: Anemia, Dehydration, Shock, Asphyxia

The use of trimethaphan is contraindicated in patients with anemia, hypovolemia, shock, asphyxia, respiratory insufficiency or other conditions in which the vasodilating and hypotensive effects of trimethaphan may pose undue risk.

References

  1. "Product Information. Arfonad (trimethaphan camsylate)." Roche Laboratories, Nutley, NJ.
Moderate

Trimethaphan (applies to Arfonad) allergies

Moderate Potential Hazard, Moderate plausibility.

Trimethaphan causes histamine release. A histamine-like reaction has been observed along the vein used for drug administration. Although it is considered a weak histamine liberator, therapy with trimethaphan should be administered cautiously in patients with allergies.

References

  1. American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
  2. "Product Information. Arfonad (trimethaphan camsylate)." Roche Laboratories, Nutley, NJ.
Moderate

Trimethaphan (applies to Arfonad) reduced blood flow

Moderate Potential Hazard, High plausibility. Applicable conditions: Liver Disease, Cardiovascular Disease, Adrenal Insufficiency, Renal Dysfunction, Diabetes Mellitus

The use of trimethaphan may reduce coronary and cerebral blood flow. Therapy with trimethaphan should be administered cautiously in patients with arteriosclerosis, cardiac disease, hepatic or renal disease, degenerative CNS disease, Addison's disease, and diabetes. Monitoring heart rate and blood pressure at frequent intervals is recommended.

References

  1. "Product Information. Arfonad (trimethaphan camsylate)." Roche Laboratories, Nutley, NJ.

Arfonad (trimethaphan camsylate) drug interactions

There are 163 drug interactions with Arfonad (trimethaphan camsylate)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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