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Nifurtimox Disease Interactions

There are 5 disease interactions with nifurtimox.

Major

Nifurtimox (applies to nifurtimox) alcohol

Major Potential Hazard, Moderate plausibility. Applicable conditions: Alcoholism

The consumption of alcohol is contraindicated when receiving treatment with nifurtimox as it may increase the incidence and severity of adverse events.

Moderate

Nifurtimox (applies to nifurtimox) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The effect of hepatic impairment on the pharmacokinetics of nifurtimox is unknown. Administer under close medical supervision on these patients.

Moderate

Nifurtimox (applies to nifurtimox) neurological/psychiatric conditions

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Seizures, Head Injury, History - Psychiatric Disorder

Patients with a history of brain injury, seizures, psychiatric disease or behavioral alterations may experience worsening of their conditions when receiving treatment with nifurtimox. This drug should be administered under close medical supervision in these patients.

Moderate

Nifurtimox (applies to nifurtimox) porphyria

Moderate Potential Hazard, Moderate plausibility.

Treatment with nifurtimox may precipitate attacks of porphyria and should be used under close medical supervision in patients with this diagnosis.

Moderate

Nifurtimox (applies to nifurtimox) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

The effect of renal impairment on the pharmacokinetics of nifurtimox is unknown, but studies suggest that the blood concentrations of the drug are increased in patients with end-stage renal disease that require hemodialysis. Administer under close medical supervision on these patients.

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Nifurtimox drug interactions

There are 12 drug interactions with nifurtimox.

Nifurtimox alcohol/food interactions

There is 1 alcohol/food interaction with nifurtimox.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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