Miltefosine Disease Interactions
There are 4 disease interactions with miltefosine:
Miltefosine (Includes Miltefosine) ↔ Sjogren-Larsson Syndrome
Severe Potential Hazard, High plausibility
Applies to: Sjogren-Larsson Syndrome
The use of miltefosine is contraindicated in patients with Sjogren-Larsson syndrome. Miltefosine undergoes metabolic cleavage in hepatocytes to release choline. The fatty alcohol-containing fragment of miltefosine is then oxidized to palmitic acid, which enters the metabolism of fatty acids. However, this oxidation is blocked in patients with Sjogren-Larsson syndrome, who have a genetic defect in fatty aldehyde dehydrogenase activity.
Miltefosine (Includes Miltefosine) ↔ Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Liver Disease
Elevations in liver transaminases (ALT, AST) and bilirubin were observed in clinical trials of miltefosine for the treatment of visceral leishmaniasis. Therapy with miltefosine should be administered cautiously in patients with liver disease, as the pharmacokinetics of miltefosine have not been studied in this population. Patients with serum ALT or AST levels 3 times or higher than the upper limit of normal and bilirubin levels 2 times or higher than the upper limit of normal were excluded from clinical trials. Liver transaminases and bilirubin should be monitored regularly during therapy.
Miltefosine (Includes Miltefosine) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction, Dehydration
Elevations in serum creatinine were observed in clinical trials of miltefosine for the treatment of cutaneous, mucosal, and visceral leishmaniasis. Therapy with miltefosine should be administered cautiously in patients with renal impairment, as the pharmacokinetics of miltefosine have not been studied in this population. Patients with serum creatinine or BUN levels 1.5 times or higher than the upper limit of normal were excluded from clinical trials. Renal function should be monitored weekly during therapy and for 4 weeks after completion of therapy. Miltefosine may commonly cause gastrointestinal adverse reactions. Patients should be advised to drink plenty of fluids to help prevent dehydration and kidney injury if they experience diarrhea or vomiting, and to seek medical attention if it is persistent or severe.
Miltefosine (Includes Miltefosine) ↔ Thrombocytopenia
Moderate Potential Hazard, Moderate plausibility
Applies to: Thrombocytopenia
Thrombocytopenia was observed in clinical trials of miltefosine for the treatment of visceral leishmaniasis. Therapy with miltefosine should be administered cautiously in patients with preexisting thrombocytopenia. Platelet counts should be monitored regularly during therapy.
miltefosine drug Interactions
There are 23 drug interactions with miltefosine
miltefosine alcohol/food Interactions
There is 1 alcohol/food interaction with miltefosine
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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