Skip to Content

Impavido (miltefosine) Disease Interactions

There are 4 disease interactions with Impavido (miltefosine):

Major

Miltefosine (applies to Impavido) Sjogren-Larsson syndrome

Major Potential Hazard, High plausibility.

The use of miltefosine is contraindicated in patients with Sjogren-Larsson syndrome. Miltefosine undergoes metabolic cleavage in hepatocytes to release choline. The fatty alcohol-containing fragment of miltefosine is then oxidized to palmitic acid, which enters the metabolism of fatty acids. However, this oxidation is blocked in patients with Sjogren-Larsson syndrome, who have a genetic defect in fatty aldehyde dehydrogenase activity.

Moderate

Miltefosine (applies to Impavido) liver disease

Moderate Potential Hazard, High plausibility.

Elevations in liver transaminases (ALT, AST) and bilirubin were observed in clinical trials of miltefosine for the treatment of visceral leishmaniasis. Therapy with miltefosine should be administered cautiously in patients with liver disease, as the pharmacokinetics of miltefosine have not been studied in this population. Patients with serum ALT or AST levels 3 times or higher than the upper limit of normal and bilirubin levels 2 times or higher than the upper limit of normal were excluded from clinical trials. Liver transaminases and bilirubin should be monitored regularly during therapy.

Moderate

Miltefosine (applies to Impavido) renal dysfunction

Moderate Potential Hazard, High plausibility. Applicable conditions: Dehydration

Elevations in serum creatinine were observed in clinical trials of miltefosine for the treatment of cutaneous, mucosal, and visceral leishmaniasis. Therapy with miltefosine should be administered cautiously in patients with renal impairment, as the pharmacokinetics of miltefosine have not been studied in this population. Patients with serum creatinine or BUN levels 1.5 times or higher than the upper limit of normal were excluded from clinical trials. Renal function should be monitored weekly during therapy and for 4 weeks after completion of therapy. Miltefosine may commonly cause gastrointestinal adverse reactions. Patients should be advised to drink plenty of fluids to help prevent dehydration and kidney injury if they experience diarrhea or vomiting, and to seek medical attention if it is persistent or severe.

Moderate

Miltefosine (applies to Impavido) thrombocytopenia

Moderate Potential Hazard, Moderate plausibility.

Thrombocytopenia was observed in clinical trials of miltefosine for the treatment of visceral leishmaniasis. Therapy with miltefosine should be administered cautiously in patients with preexisting thrombocytopenia. Platelet counts should be monitored regularly during therapy.

Impavido (miltefosine) drug interactions

There are 6 drug interactions with Impavido (miltefosine)

Impavido (miltefosine) alcohol/food interactions

There is 1 alcohol/food interaction with Impavido (miltefosine)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.