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Increlex (mecasermin) Disease Interactions

There are 4 disease interactions with Increlex (mecasermin):


Mecasermin (Includes Increlex) ↔ Diabetics

Moderate Potential Hazard, Moderate plausibility

Applies to: Diabetes Mellitus

Mecasermin has insulin-like hypoglycemic effects, therefore, care should be taken when prescribing this agent to diabetic patients. It is recommended to monitor blood glucose levels in these patients until a well-tolerated dose is established and subsequently as medically indicated.


Mecasermin (Includes Increlex) ↔ Lymphoid Tissue Hypertrophy

Moderate Potential Hazard, Moderate plausibility

Applies to: Sleep Apnea

Lymphoid tissue (e.g., tonsillar and adenoidal) hypertrophy associated with complications such as snoring, sleep apnea, and chronic middle-ear effusions have been reported with the use of mecasermin. Patients presenting these complications should be periodically examined to rule-out the occurrence of lymphoid tissue hypertrophy. Care should be taken when prescribing mecasermin to these patients.


Mecasermin (Includes Increlex) ↔ Scoliosis

Moderate Potential Hazard, Moderate plausibility

Applies to: Scoliosis

Because mecasermin increases growth rate, patients who experience rapid growth should be closely monitored for any onset of a limp or complaints of hip or knee pain. Patients with a history of scoliosis who are treated with mecasermin should be monitored for progression of scoliosis. Care should be taken when prescribing this agent to patients with a history of scoliosis.


Mecasermin (Includes Increlex) ↔ Visual Complications

Moderate Potential Hazard, Moderate plausibility

Applies to: Visual Defect/Disturbance

Intracranial hypertension with papilledema, visual changes, headache, nausea and/or vomiting have occurred in patients treated with mecasermin. Ophthalmologic examination is recommended at the initiation and periodically during the course of mecasermin therapy. Assessment is recommended prior to prescribing this agent to patients with ocular complications.

Increlex (mecasermin) drug Interactions

There are 35 drug interactions with Increlex (mecasermin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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