Laronidase Disease Interactions

Patients with compromised respiratory function or acute respiratory disease may be at risk of serious acute exacerbation of their respiratory compromise due to infusion reactions during laronidase therapy and require additional monitoring. Patients with compromised respiratory function or acute febrile or respiratory illness at the time of laronidase infusion may be at higher risk of life-threatening complications from hypersensitivity reactions. Careful consideration should be given to the patient's clinical status before laronidase administration and delaying the laronidase infusion should be considered.

Caution is recommended when administering laronidase to patients susceptible to fluid overload, or patients with acute underlying respiratory illness or compromised cardiac and/or respiratory function for whom fluid restriction is indicated; these patients may be at risk of serious exacerbation of their cardiac or respiratory status during infusions. Appropriate medical support and monitoring measures should be readily available during laronidase infusion, and some patients may require prolonged observation times that should be based on the needs of each patient.