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Fulvicin U/F Disease Interactions

There are 3 disease interactions with Fulvicin U/F (griseofulvin).

Major

Griseofulvin (applies to Fulvicin U/F) hepatic dysfunction

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of griseofulvin is contraindicated in patients with hepatocellular failure, as animal data has shown that this drug may cause hepatocellular necrosis. The use of griseofulvin has not been adequately studied in patients with liver disease, although it is known that griseofulvin is primarily metabolized by the liver. Therapy with griseofulvin should be administered very cautiously in patients with liver impairment, and the dosing adjusted or discontinued according to clinical response.

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Major

Griseofulvin (applies to Fulvicin U/F) porphyria

Major Potential Hazard, High plausibility.

The use of griseofulvin is contraindicated in patients with porphyria. Griseofulvin has been shown to cause disturbances in porphyrin metabolism in laboratory animals.

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Moderate

Griseofulvin (applies to Fulvicin U/F) lupus erythematosus

Moderate Potential Hazard, Moderate plausibility.

The use of griseofulvin has been associated with the development of lupus erythematosus and lupus-like syndromes, as well as exacerbation of the disease. Griseofulvin therapy should be withdrawn in patients experiencing worsening of preexisting lupus until another cause can be identified.

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Fulvicin U/F drug interactions

There are 264 drug interactions with Fulvicin U/F (griseofulvin).

Fulvicin U/F alcohol/food interactions

There is 1 alcohol/food interaction with Fulvicin U/F (griseofulvin).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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