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SMOFlipid Disease Interactions

There are 2 disease interactions with SMOFlipid (fat emulsion).

Major

Fat emulsion (applies to SMOFlipid) hypertriglyceridemia

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hyperlipidemia, Diabetes Mellitus, Obesity

Parenteral nutrition fat emulsion products are contraindicated in patients with severe lipid metabolism disorders characterized by hypertriglyceridemia (serum triglycerides greater than 1000 mg/dL). Patients with conditions such as inherited lipid disorders, diabetes mellitus, obesity, or metabolic syndromes are at increased risk while in treatment and should be monitored closely.

References (1)
  1. (2023) "Product Information. Smoflipid (fat emulsion, intravenous)." Fresenius Kabi USA, LLC, SUPPL-10
Moderate

Fat emulsion (applies to SMOFlipid) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Parenteral nutrition fat emulsion products may cause aluminum toxicity and patients with renal impairment, including preterm neonates, are at increased risk. Caution and monitoring are advised.

References (1)
  1. (2023) "Product Information. Smoflipid (fat emulsion, intravenous)." Fresenius Kabi USA, LLC, SUPPL-10

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SMOFlipid drug interactions

There is 1 drug interaction with SMOFlipid (fat emulsion).

SMOFlipid alcohol/food interactions

There are 2 alcohol/food interactions with SMOFlipid (fat emulsion).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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