Defitelio Disease Interactions
There is 1 disease interaction with Defitelio (defibrotide).
Defibrotide (applies to Defitelio) bleeding
Major Potential Hazard, Moderate plausibility.
The use of defibrotide may increase the risk of bleeding in patients with hepatic veno-occlusive disease after hematopoietic stem-cell transplantation. Discontinue anticoagulants and fibrinolytic agents prior to defibrotide treatment, and consider delaying the start of defibrotide administration until the effects of the anticoagulant have subsided. It is recommended to withhold therapy with defibrotide in patients with active bleeding and to monitor patients for signs of bleeding. Discontinue treatment with defibrotide in patients that develop bleeding and treat the underlying cause, and provide supportive care until the bleeding has stopped.
References (1)
- (2016) "Product Information. Defitelio (defibrotide)." Jazz Pharmaceuticals
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Defitelio drug interactions
There are 144 drug interactions with Defitelio (defibrotide).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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