Danicopan Disease Interactions
There are 2 disease interactions with danicopan.
Danicopan (applies to danicopan) infections
Major Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral
Initiation of therapy with danicopan is contraindicated in patients with unresolved serious infection caused by encapsulated bacteria, including Neisseria meningitidis, Streptococcus pneumoniae, or Haemophilus influenzae type B. Complete or update vaccination against encapsulated bacteria at least 2 weeks prior to administration of the first dose of this drug; follow clinical vaccination guidelines for patients on complement inhibitors. Antibacterial drug prophylaxis is recommended in patients who require urgent therapy and who are not up to date on vaccinations.
References
- (2024) "Product Information. Voydeya (danicopan)." Alexion Pharmaceuticals Inc
Danicopan (applies to danicopan) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Avoid use of danicopan in patients with severe liver dysfunction (Child-Pugh C); studies have not been conducted in this population. No dose adjustment of danicopan is required in patients with mild to moderate liver dysfunction (Child-Pugh A or B).
References
- (2024) "Product Information. Voydeya (danicopan)." Alexion Pharmaceuticals Inc
Danicopan drug interactions
There are 193 drug interactions with danicopan.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.